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Tranylcypromine is an antidepressant used to treat depressive illnesses. This type of condition is a mood disorder that causes a persistent feeling of sadness and loss of interest. It affects how you feel, think, and behaves. This may also lead to a variety of emotional and physical problems. Although depressive illness may occur only once during your life people typically have multiple episodes. During these episodes, symptoms occur most of the day, nearly every day, and may include:

  • Angry outbursts, irritability, or frustration
  • Feelings of tearfulness, sadness, hopelessness, or emptiness
  • Sleep disturbances including insomnia or sleeping too much
  • Loss of interest or pleasure in most or all normal activities
  • Reduced appetite and weight loss or increased cravings for food and weight gain
  • Tiredness and lack of energy even in small tasks
  • Slowed thinking, making a decision, and concentrating
  • Agitation, anxiety, or restlessness
  • Unexplained physical problems such as back pain or headaches

For many people with depression, symptoms usually are severe enough to cause noticeable problems in day-to-day activities (work, school, social activities or relationships with others). Some people may feel generally miserable or unhappy without really knowing why.

Tranylcypromine is in the class of medications called monoamine oxidase inhibitors. This medication treats the illness by restoring the balance of certain natural substances in the brain. This can improve your mood and feelings of well-being. The Food and Drug Administration (FDA) has already approved this medication. This product is supplied as film-coated tablets intended for oral use. Each tablet contains Tranylcypromine as an active ingredient. This is available in the dosage form of 10 mg.

How does Tranylcypromine work?

Depression is a complicated disease that is thought to be linked to an imbalance of chemicals within the brain. When depression occurs, there may be a decrease in the number of chemicals released from nerve cells in the brain. These chemicals are called monoamines. Monoamines are broken down by a chemical called monoamine oxidase. Tranylcypromine prevents monoamine oxidase from breaking down the monoamines. This results in an increased amount of active monoamines in the brain. By increasing the number of monoamines in the brain, the imbalance of chemicals thought to cause depression is altered. This helps relieve depression.

How to use Tranylcypromine?

Tranylcypromine is to be taken by mouth. This is usually taken in divided doses or as directed by your doctor. You may take each dose with or without a meal. Swallow the tablet as a whole with a full glass of water. Do not break, chew, or crush it. The recommended dosage is based on your medical condition, age, and response to the treatment. You should take the right dose, not more or less. Remember to take it at the same time and in the same way each day. Do not suddenly stop taking this medication without the consent of your doctor. It may cause another complication or may worsen your current condition. For the best benefit from this product, take it regularly. If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for the missed dose.

It may take between two to four weeks for the benefits of this medicine to appear. You must keep taking it even if it doesn’t seem to make much difference at first. If you feel your depression has got worse or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your doctor.

What are the side effects of Tranylcypromine?

Common side effects:

  • Vision problems
  • Frequent headaches
  • Restlessness
  • Sensitivity to light
  • Drowsiness
  • Weakness
  • Diarrhea
  • Nausea
  • Loss of appetite
  • Constipation
  • Chills
  • Stomach pain
  • Dry mouth
  • Numbness or tingly feeling
  • Problems sleeping
  • Decreased urination
  • Ringing in your ears
  • Blurred vision
  • Impotence or difficulty having an orgasm

Tell your doctor if you have unlikely but serious side effects of this drug including:

  • Mental or mood changes
  • Fainting
  • Shaking or tremor
  • Muscle stiffness
  • Swollen ankles or legs
  • Shivering
  • Unusual weight gain

Get emergency medical help if you have experienced any signs of an allergic reaction such as:

  • Hives or itching
  • Trouble or difficulty breathing
  • Swelling of your lips, face, tongue, or throat

Warnings and Precautions

  • While having this treatment, limit alcoholic beverages.
  • Do not take Tranylcypromine if you are allergic to one or any of its ingredients.
  • This is not recommended for pregnant or breastfeeding women.
  • You should not share this or any of your drugs with others even if they have the same symptoms as yours.
  • This medicine may make you feel sleepy or dizzy. If affected, you should avoid potentially unsafe activities such as driving or using any machinery.
  • Call for medical help if you have any signs of an overdose.
  • You must not consume food that is rich in the amino acid tyramine while you are having this treatment. It is because the combination could cause a dangerous increase in blood pressure.
  • This drug can interact with various other medicines including those that can be bought without a prescription. It is important to check with your pharmacist before taking any over-the-counter drugs.
  • This can occasionally cause your blood pressure to drop when you move from a lying down or sitting position, especially when starting this treatment.
  • If you are due to have elective surgery or dental procedures, this drug should be stopped two weeks beforehand. You should follow the instructions given by your doctor.
  • Your doctor may also want to monitor your kidney function while having this medication.
  • Keep this drug at room temperature far from heat, moisture, and far from the reach of children.

This should be used with caution in:

  • Agitated people
  • Elderly people
  • Bipolar disorder
  • People with diabetes or epilepsy
  • People with hereditary blood disorders called porphyrias

This should not be used in:

  • Children
  • People with a history of liver disease
  • People with disease of a blood vessel in and around the brain
  • Those with severe cardiovascular disease