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Ticarcillin-Clavulanate

Formula Drugs

Where is Ticarcillin-Clavulanate used?

Ticarcillin-Clavulanateis a prescription used for the treatment of certain bacterial infections such as bacterial infections of the:

  • Lower respiratory tract
  • Bones or joints
  • Inside the abdomen
  • Skin and soft tissue
  • Kidney

Ticarcillin is a penicillin-type antibiotic and Clavulanate is a medicine that stops bacteria from deactivating the Ticarcillin. The Food and Drug Administration (FDA) has already approved this prescription

How does Ticarcillin-Clavulanate work?

Ticarcillin works by interfering with the ability of bacteria to form cell walls. The cell walls of bacteria are important for them to survive. They preserve undesirable substances from entering their cells and stop the substances of their cells from leaking out. Ticarcillin damages the bonds that hold the bacterial cell wall together. This allows holes to appear in the cell walls and kills the bacteria.

Clavulanate inhibits the action of the beta-lactamases produced by certain bacteria. It stops these bacteria from inactivating the Ticarcillin and leaves the bacteria susceptible to attack. Clavulanate, as a result, increases the variety of bacteria that Ticarcillin can kill.

How is Ticarcillin-Clavulanate taken?

  • This medication is injected onto a vein through an IV. Use a disposable needle only once then throw it away in a puncture-proof container. 
  • This is usually given for 10 to 14 days depending on the infection being treated.
  • Ticarcillin-Clavulanate should be mixed with a liquid before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
  • Shake the mixture well to dissolve the medicine completely. The mixture should appear light to dark yellow.
  • After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture.
  • Carefully follow the mixing and storage instructions provided with your medicine.

Use this medication until the full recommended length of time is done. Your symptoms might improve before the infection is cleared. Missing doses might as well increase your risk of further infection that is resistant to antibiotics.

What are the possible side effects of Ticarcillin-Clavulanate?

Common side effects:

  • Nausea
  • Gas
  • Mild diarrhea
  • Headache
  • Vomiting 
  • Injection site reactions (swelling, pain, or burning)

What are the precautions in using Ticarcillin-Clavulanate?

  • This is not recommended for use in people allergic to penicillin. Let your doctor know if you have any allergies. This medication may have inactive ingredients that might cause an allergic reaction. 
  • This should be used with caution in people with decreased kidney function, severely decreased liver function, people on a low sodium diet, or low levels of potassium in their blood. 
  • Certain medicines should not be used during breastfeeding or pregnancy. However, other medicines may be safely used in breastfeeding or pregnancy providing the benefits to the mother outweighs the threats to the unborn baby. Let your doctor know if you are planning a pregnancy or pregnant, before using any medication.
  • This prescription passes into breast milk in small amounts. However, it is unlikely to have harmful effects on a nursing infant at normal doses. Seek further medical advice from your doctor.
  • It is important to tell your doctor if you have any other medications incusing vitamins or herbal supplements.