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What condition does Siponimod treat?

Siponimod is a prescription drug that is used to treat relapsing multiple sclerosis. Multiple sclerosis causes damage to the central nervous system, including the spinal cord and brain. During relapses, myelin, the insulation protecting nerves, is attacked by the immune system. This medicine helps prevent the immune system cells from attacking the nerves in your spinal cord and brain.

This prescription medicine is a sphingosine 1-phosphate (S1P) receptor modulator. The drug helps lessen the number of episodes of disease worsening or relapses. Siponimod may also prevent or delay disability. Siponimod is a prescription approved by the U.S. Food and Drug Administration (FDA). This medication comes as a tablet for oral use. 

How does Siponimod work?

Siponimod binds with high affinity to S1P receptors. It blocks the capability of lymphocytes to egress from lymph nodes. It also lessens the number of lymphocytes in peripheral blood. The mechanism by which the medicine exerts therapeutic effects in multiple sclerosis is unidentified. However, it may involve the reduction of lymphocyte migration into the central nervous system.

What is the recommended dosage for Siponimod?

The dosage depends on your medical condition, age, and response. Your doctor may direct you to start this at a low dose and gradually increase it. Follow your doctor’s instructions carefully. 

Usually, Siponimod is taken once daily. It is to be taken by mouth with a full glass of water. You may take each dose with or without food. Don’t forget to take each dose at the same time each day. For the best benefit, take it regularly. Your doctor will tell you how much you should take. If you missed a dose, call your doctor for instructions.

What are the side effects of Siponimod?

Common side effects:

  • Headache
  • Swelling of extremities
  • Dizziness
  • Nausea
  • Diarrhea
  • Pain in the extremities
  • High blood pressure 
  • Increased transaminase 

If these side effects persist or get worse, call your doctor right away. 

What are the precautions in taking Siponimod?

  • Do not stop taking Siponimod without consulting your doctor. 
  • Tell your doctor if you are allergic to this drug before using it. 
  • Inform your doctor if you have any medical history or current medications including herbal remedies or vitamins.
  • If you are a pregnant or breastfeeding woman, consult your doctor first. 
  • Even if they have the same symptoms as yours, you should not share this or any of our medications. 
  • During treatment with this medicine, for 1 week before starting treatment, or for 1 month after your final dose, do not get any vaccinations without consulting your doctor first. Before starting your treatment with Siponimod, consult your doctor about vaccinations you may need. 
  • Tell your doctor if you have not received the chickenpox vaccine or have never had chickenpox. Your doctor may order a blood test to see if you have been exposed to chickenpox. You may need to receive the chickenpox vaccine and then wait one month before beginning your treatment with Siponimod. 
  • Keep this at a dry and clean place far from heat and moisture.