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Rasagiline

Rasagiline

Where is Rasagiline used?

Rasagiline is used to treat symptoms of Parkinson’s disease. This disease affects movement and is a progressive nervous system disorder. The symptoms begin slowly and sometimes it starts with a barely noticeable tremor just in one hand.

This is used alone or in combination with other medications such as carbidopa/levodopa. This helps improve symptoms such as stiffness, shakiness, and difficulty moving. Rasagiline may also help lessen the amount of ‘off’ time or periods of slow movement stiffness. The Food and Drug Administration (FDA) has already approved this prescription. Rasagiline is supplied as a tablet.

How does Rasagiline work?

Rasagiline is a type of medicine called a selective monoamine-oxidase-B inhibitor (MAOI-B). This increases the levels of a substance in the brain called dopamine. Dopamine is a substance known as a neurotransmitter. Neurotransmitters are found in the brain and nervous system. These are involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced or absent in the brains of people with Parkinson’s disease. This is thought to be the cause of disease symptoms. The mainstay of treating Parkinson’s disease is to replace dopamine in the brain.

Natural dopamine released from nerve cells in the brain is usually broken down by an enzyme called MAOI-B. Rasagiline works by blocking the action of this enzyme which prevents the MAOI-B from breaking down the dopamine. This results in an increased amount of active dopamine in the brain. Therefore, this lessens the symptoms of Parkinson’s disease.

How is Rasagiline taken?

Rasagiline is usually taken once a day. This is to be taken as directed by your doctor. Each dose may be taken with or without a meal. Do not suddenly stop this treatment without the consent of your doctor. Drink plenty of fluids while having this treatment.

The tablet is to be taken by mouth depending on the dosage that will be prescribed to you. Take each dose exactly as it is given by your doctor. Do not take in larger or smaller amounts or for longer than the prescription. Your doctor may give you a lower dose to start and gradually increase it.

What are the possible side effects of Rasagiline?

Common side effects:

  • Dizziness
  • Spinning sensation
  • Headache
  • Joint pain
  • Nausea
  • Heartburn
  • Dry mouth
  • Muscle pain
  • Stomach upset or abdominal pain
  • Vomiting
  • Loss of appetite
  • Diarrhea
  • Constipation

Tell your doctor right away if you have these side effects:

  • Nausea
  • Shakiness
  • Muscle stiffness

What are the precautions in taking Rasagiline?

  • Rasagiline may make you dizzy. Do not operate machinery or do any activity that needs your full alertness.
  • You should not share this with others even if they have the same symptoms as yours.
  • Tell your doctor if you ever had an allergic reaction to this drug. This may contain an inactive ingredient that causes an allergic reaction.
  • Use this with caution in people with decreased liver function.
  • Do not use this in people taking monoamine oxidase inhibitor medicines.
  • This is not recommended for use in children and adolescents under 18 years of age. Its safety and efficacy have not been studied yet in this age group.
  • Before using this medication, let your doctor know if you have any medical history especially of liver or kidney disease, stroke, and high or low blood pressure.
  • While having treatment, limit alcoholic beverages.
  • If you have any signs of an overdose, call your doctor right away.