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Promethazine Hydrochloride

Formula Drugs

Promethazine Hydrochloride is used to:

  • Relieve symptoms of allergic reactions such as hay fever, nettle rash, or insect bites and stings
  • Prevents and treats sickness and  vomiting such as travel sickness or sickness associated with vertigo
  • Short-term treatment for insomnia

Allergic reactions occur when your immune system reacts to a foreign substance. Your immune system produces substances known as antibodies. When you have allergies, your immune system makes antibodies that identify a particular allergen as harmful even though it is not. The severity of allergies varies from person to person and can range from minor irritation to anaphylaxis. Allergy symptoms can affect your airways, sinuses/nasal passages, skin, and digestive system.

Vertigo is a sensation of spinning dizziness. It can happen when there is a problem with the inner ear, brain, or sensory nerve pathway. Vertigo can happen at any age but it is common in people aged 65 years and over. This condition can be temporary or long-term and may affect a person’s ability to function in daily life.

Insomnia is difficulty falling asleep or staying asleep. This may be characterized based on its duration; acute insomnia often occurs because of life circumstances. Chronic insomnia is disrupted sleep that happens at least 3 nights per week and lasts at least 3 months. People with this disorder can feel dissatisfied with their sleep and usually experience:

  • Low energy
  • Fatigue
  • Mood disturbances
  • Difficulty concentrating
  • Decreased performance at school or work

Promethazine Hydrochloride is a type of medicine called sedating antihistamine. This prevents the actions of histamine that your body makes during an allergic reaction. Its other effect is by affecting other natural substances and by acting directly on certain parts of the brain. This product is supplied as tablets for oral use. Each tablet is available in the dosage strengths of 25 mg and 50 mg. The Food and Drug Administration (FDA) has already approved this prescription.

How does Promethazine Hydrochloride work?

For allergies, Promethazine Hydrochloride blocks histamine from binding to its receptors in various parts of the body. Histamine is a substance produced by the body as part of its defense mechanisms. This medication stops it causing the symptoms of an allergic reaction.

For vertigo, this drug blocks histamine receptors in an area of the brain called the vomiting center. This part of the brain is activated when it gets nerve messages to form a part of the inner called the vestibular apparatus. It’s responsible for making you feel sick and for the vomiting reflex. Promethazine Hydrochloride stops the vomiting center from being activated.

For insomnia, this is known as a sedating antihistamine because it enters the brain in significant quantities and makes you feel sleepy. You can use this drug for a short period. It is to help you get to sleep if you are having trouble sleeping.

How to use Promethazine Hydrochloride?

Promethazine Hydrochloride is to be taken by mouth. The tablet is to be swallowed as a whole with a full glass of water. Do not break, chew, or crush the drug. For allergies, this is usually taken one to four times a day before meals at bedtime. For travel sickness, this is taken 30 to 60 minutes before travel and taken again after 8 to 12 hours if needed. For longer trips, it is usually in the morning and before the evening meal on each day of travel. Drink plenty of fluids while having this treatment. Doing so may lessen the risk of certain side effects. The recommended dosage is based on your medical condition, age, and response to the treatment. Your doctor may direct you to start at a lower dose and eventually increase it.

You should not take more or less than it is given. Even if you feel well, continue to take the medication until the full prescription is done. Do not suddenly stop taking Promethazine Hydrochloride without the consent of your doctor. If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for the missed dose. Let your doctor know if your condition worsens or does not improve.

What are the side effects of Promethazine Hydrochloride?

Common side effects:

  • Dizziness
  • Drowsiness
  • Blurred vision
  • Anxiety
  • Stuffy nose
  • Dry mouth
  • Weight gain
  • Ringing in your ears
  • Impotence
  • Swelling in your hands or feet
  • Constipation
  • Trouble having an orgasm

Stop using Promethazine Hydrochloride and call your doctor right away if you have:

  • A light-headed feeling like you might pass out
  • Weak or shallow breathing
  • Severe drowsiness
  • Seizure
  • Agitation
  • Confusion
  • Yellowing of the skin or eyes (jaundice)
  • Easy bleeding or bruising
  • Uncontrolled muscle movements in your face
  • Sudden weakness or ill feeling, chills, fever, or mouth sores
  • Sore throat or trouble swallowing
  • Severe nervous system reaction (sweating, tremors, confusion, very stiff muscles, and high fever)

Warnings and Precautions

  • Promethazine Hydrochloride should only be used during pregnancy if your doctor tells you to do so. This should not be used during the last two weeks of pregnancy. If taken during this time it may cause irritability or excitement in the baby after birth. If you get pregnant while taking this medicine, call your doctor right away.
  • If you ever had an allergic reaction to this product, let your doctor know before taking a dose. Tell as well to your doctor if you have any allergies.
  • This is not recommended for use in children under two years of age.
  • This should be used with caution in people who are over 65 years old, who have kidney or liver problems, and who have severe heart disease.
  • Before using Promethazine Hydrochloride, inform your doctor if you have any medical history especially of breathing problems, heart disease, difficulty urinating, and high pressure in the eye.
  • This may make you more sensitive to the sun. Limit your time in the sun. When outdoors, use sunscreen and wear protective clothing.
  • While having this treatment, avoid alcoholic beverages.