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Prochlorperazine is a prescription used to treat nausea and vomiting. This used in a lower dose to treat the condition. This prescription may also be used for the treatment of anxiety and a certain psychiatric illness called schizophrenia.

Nausea and vomiting are not a disease but rather, these are symptoms of many different conditions such as:

  • Motion sickness
  • Food poisoning
  • Brain injury
  • Migraines
  • Appendicitis

Sometimes, it can also be symptoms of more serious diseases. Nausea and vomiting differ from each other. Nausea is an uneasiness of the stomach that often accompanies the urge to vomit. Vomiting is the forcible voluntary or involuntary emptying or throwing up of stomach contents through the mouth. Nausea and vomiting may happen in both children and adults.

Anxiety involves more than temporary worry or fear. That it does not go away and can get worse over time. The symptoms of this condition can interfere with daily activities such as school, job, and relationships. Experiencing occasional anxiety is a normal part of life. Symptoms may start during childhood or the teen years and continue into adulthood.

Schizophrenia affects how a person feels, thinks, and behaves. It can be a chronic or severe mental disorder. People with this illness may seem like they have lost touch with reality. Schizophrenia may result in some combination of delusions, hallucinations, and extremely disordered thinking.

Prochlorperazine is a type of drug known as a phenothiazine. This blocks dopamine receptors in the brain. Dopamine is a natural compound called a neurotransmitter that is involved in transmitting messages between brain cells. It is known to be involved in regulating mood and behavior. It also acts in an area of the brain that controls nausea and vomiting. This is a prescription approved by the Food and Drug Administration (FDA). This product comes as a tablet for oral use. Each tablet is available in the dosage forms of 5 mg and 10 mg with an active ingredient of Prochlorperazine.

How does Prochlorperazine work?

In nausea and vomiting, Prochlorperazine blocks dopamine receptors found in the chemoreceptor trigger zone (CTZ). Wherein, it stops it from sending the messages to the vomiting center that causes nausea and vomiting. Vomiting is controlled by an area of the brain called the vomiting center. The vomiting center is responsible for causing feelings of sickness and for the vomiting reflex. It activates when receives nerve messages from another area of the brain called CTZ and when it receives nerve messages from the gut.

In psychiatric illness, this medicine is sometimes described as a neuroleptic or a major tranquilizer. It has a calming effect on people suffering from anxiety. Schizophrenia is thought to be caused by the overactivity of dopamine in the brain. By blocking dopamine receptors, Prochlorperazine decreases the action of dopamine in the brain and it helps control psychotic symptoms.

How to use Prochlorperazine?

The prescribed dosage is based on your medical condition, age, and response to it. Your doctor may direct you to start at a lower dose and eventually increase it. Prochlorperazine is to be taken by mouth with a full glass of water. Drink plenty of fluids while having this treatment. Doing so may lessen the risk of certain side effects. It is usually taken 3 to 4 times a day or as directed by your doctor. You may take each dose with or without a meal. Swallow the tablet as a whole. Do not break, chew, or crush it. You must take this medication exactly as it is given by your doctor. You should not take less or more often than the prescription.

To help you remember, take it at the same time and in the same way each day. Take it regularly for the best result from this product. If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the doses to make up for the missed dose. Do not suddenly stop taking Prochlorperazine without the consent of your doctor. It is important to continue taking this even if you feel well. Let your doctor know if your condition gets worse or does not improve.

What are the side effects of Prochlorperazine?

Common side effects:

  • Drowsiness
  • Dizziness
  • Sleep problems
  • Anxiety
  • Dry mouth
  • Strange dreams
  • Blurred vision
  • Stuffy nose
  • Breast swelling or discharge
  • Constipation
  • Weight gain
  • Missed menstrual periods
  • Impotence
  • Swelling in hands or feet
  • Mild itching
  • Trouble having an orgasm
  • Skin rash
  • Low blood pressure
  • Headache

Stop taking Prochlorperazine and call your doctor right away if these occur:

  • Any new or unusual muscle movements you cannot control
  • Tremors or shaking in your arms or legs
  • Uncontrolled muscle movements  in your face ( lip-smacking, chewing, tongue movement, blinking or eye movement)
  • Little or no urinating
  • Stiffness or muscle spasms in your neck
  • Trouble swallowing
  • Fast or slow heart rate
  • A light-headed feeling
  • Low white blood cell counts
  • Severe nervous system reaction

Warnings and Precautions

  • This product is not recommended for use in children younger than 2 years or in children going through surgery.
  • This is also not recommended for use in elderly people with dementia.
  • Before taking a dose of Prochlorperazine, tell your doctor if you have any medical history especially of breathing problems, liver disease, stomach problems, or certain brain disorders.
  • Prochlorperazine may make you dizzy. Do not use any machinery or do anything that needs your alertness.
  • This medication may make you more sensitive to the sun. Limit your time in the sun. Use sunscreen and wear protective clothing when outdoors. Tell right away to your doctor if you get sunburned or have skin blisters.
  • This may also may you sweat less which makes you more likely to get heatstroke. Avoid doing things that may cause you to overheat.
  • During pregnancy, this drug should only be used when needed. If you are breastfeeding women, consult your doctor first before taking a dose.
  • Let your doctor know if you have ever had an allergic reaction to this drug. Tell as well if you have any allergies. This product may have an inactive ingredient that causes an allergic reaction.