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What condition does Ponatinib treat?

Ponatinib is used for the treatment of certain blood cancer:

  • Acute lymphoblastic leukemia (ALL)
  • Chronic myelogenous leukemia (CML)

ALL occurs when the bone marrow makes excessive immature lymphocytes. It may affect platelets, red and white blood cells.

CML is a disease in which the bone marrow makes too many white blood cells. It is a slowly progressing blood and bone marrow disease. It usually occurs during or after middle age and rarely occurs in children.

Ponatinib belongs to the class of medications called kinase inhibitors. It comes as a tablet for oral use. Each tablet is available as white and round film-coated. The Food and Drug Administration (FDA) has already approved this prescription.

How does Ponatinib work?

Ponatinib is thought to block tumor cell development in some ways. This medication targets several proteins called tyrosine kinases. It is on the surface of cancer cells, as well as targets within the cell. Some of these targets are thought to be involved in angiogenesis or the making of blood vessels.

What is the recommended dosage for Ponatinib?

The dosage is based on your medical condition and response. It is important to take it exactly as it is prescribed. Do not take more than or more often than the prescription.

This medicine is to be taken by mouth with a full glass of water. It is usually taken once a day. Swallow the tablet as a whole. Do not break or chew it. Do not lie down for about 10 minutes after taking a dose. If stomach upset occur, you may take it with food, milk, or an antacid.

What are the side effects of Ponatinib?

  • Nausea
  • Stomach or abdominal pain
  • Headache
  • Skin rash
  • Tiredness
  • Joint pain
  • Dry skin
  • Constipation
  • Fever

If these side effects persist or worsen, call for medical help right away.

What are the precautions in taking Ponatinib?

  • Before taking this medicine, inform your doctor if you are allergic to it. This medication may contain an inactive ingredient that causes an allergic reaction.
  • Inform your doctor if you have current medications or treatments as well as any medical history. 
  • This drug may make you feel dizzy. Do not use any machinery or do anything that requires your alertness.
  • Do not twice the prescribed dosage to avoid some other complications.
  • Tell your doctor if you are breastfeeding or you have a plan to breastfeed. You should not breastfeed while taking this medicine and for 6 days after your final dose.
  • You should know that your blood pressure might increase during your treatment with this medicine. Your doctor will probably monitor your blood pressure during your treatment.
  • If you are having surgery, including dental surgery, inform the doctor or dentist that you are taking this medicine. If you are scheduled to have surgery, your doctor will tell you to stop taking this for at least 7 days before the surgery or procedure. Your doctor will tell you when to start taking Ponatinib again after your surgery.