Pentosan Polysulfate Sodium

August 31, 2021

Medicine

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What condition does Pentosan Polysulfate Sodium treat?

Pentosan Polysulfate Sodium is recommended for the treatment of pain and discomfort from a certain bladder disorder or called interstitial cystitis. It is a chronic bladder issue that has a feeling of pain and pressure in the bladder area. This medication is a weak ‘blood thinner’. This may also increase the risk of bruising/bleeding.

This prescription is a low molecular weight heparin-like compound. It contains anticoagulant and fibrinolytic effects. Pentosan Polysulfate Sodium is supplied in white opaque hard gelatin capsules for oral use. This medication was approved by the Food and Drug Administration (FDA) in 1996.

How does Pentosan Polysulfate Sodium work?

Pentosan Polysulfate Sodium is a polymer of xylose hydrogen sulfate. It has two sulfate groups for each carbohydrate monomer. It binds Fibroblast growth factors (FGFs) and also the other heparin-binding growth factors.

This medication may work by establishing a layer on the bladder wall and defending it from harmful substances in the urine.

What is the recommended dosage for Pentosan Polysulfate Sodium?

The recommended dosage is based on your medical condition and response.

This medication is to be taken by mouth at least 1 hour before or 2 hours after meals. It is usually taken 3 times a day or as directed by your doctor. To help you remember, take it at the same time each day.

Use this regularly to get the most benefit from it. Follow the prescription of your doctor very carefully.  Do not take it more often than prescribed. Let your doctor know if your condition worsens or does not improve after 3 months.

What are the side effects of Pentosan Polysulfate Sodium?

Common side effects:

• Hair loss
• Diarrhea
• Nausea
• Headache
• Abdominal pain
• Stomach upset or pain
• Dizziness
• Itching or skin rash
• Depressed mood

What are the precautions in taking Pentosan Polysulfate Sodium?

• Before using this drug, let your doctor know if you have any medical history or current medication/treatments.
• Tell your doctor if you have any allergies or if you ever had an allergic reaction to this drug. This product may contain inactive ingredients that may cause an allergic reaction.
• You should not share this with others even if they have the same symptoms as yours.
• This should be used only when needed for pregnant women. If you are a breastfeeding woman, consult your doctor first before taking this drug.
• Your doctor will need to check your progress every 3 months to help determine how long to treat you with this medication. You may also need vision examinations and blood tests to check for certain side effects.
• If you need surgery, tell your surgeon you currently take this medication. You may need to stop for a short time.
• Ask a doctor before using any medication that has ibuprofen, aspirin, or similar ingredients. This includes medication for fever, pain, cold/flu symptoms, or swelling.
• Tell your doctor about all your other medications, especially medication used to prevent blood clots and a blood thinner.
• Tell your doctor if you ever had an ulcer, hemophilia, aneurysm, intestinal blockage, low platelet count, spleen disease, or liver disease.