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Naldemedine is a prescription used for the treatment of constipation that is caused by pain medicines called opioids. Constipation is an irregular bowel movement or difficult passage of stools. That sometimes it persists for several weeks or longer. This medication blocks the effect of opioids on the gut without blocking the effects on pain.
Naldemedine is used in people who have been taking opioid pain medicine for at least 4 weeks. It is for the treatment of chronic pain that is not caused by cancer.
How does Naldemedine work?
Naldemedine binds to and antagonizes opioid receptors. The binding of opioid agonists to peripheral mu-opioid receptors slows the transit of feces. It is through the intestine resulting in constipation. By antagonizing mu-opioid receptors, Naldemedine inhibits this effect.
Why use Naldemedine?
Naldemedine belongs to the class of medications known as opioids antagonists. An opioid is sometimes called narcotic. This helps lessen constipation. This is a prescription approved by the Food and Drug Administration (FDA). Naldemedine is supplied as 0.2 mg for oral use. This contains Naldemedine as an active ingredient. It is white to light tan powder that is soluble in methanol, slightly soluble in alcohol and water.
How to use Naldemedine?
Naldemedine is to be taken by mouth. You may take each dose with or without a meal. This is usually taken once a day. Swallow the medicine as a whole with a full glass of water. Remember to take it at the same time each day.
The recommended dose is based on your condition, age, and response to the treatment. It is very important that you take this prescription exactly as it is given. Do not take more often or less than the instruction of your doctor.
What are the side effects of Naldemedine?
- Abdominal pain
- Joint pain or stiffness
- Loss of appetite
Warnings and Precautions
- You should not use Naldemedine if you have a blockage in your stomach or intestines.
- Stop using this drug and call your doctor right away if you have severe abdominal pain that does not go away.
- Tell your doctor if you have symptoms of opioid withdrawal.
- Before taking this, tell your doctor if you are allergic to it. Tell also if you have a stomach ulcer, liver disease, or intestinal disorder.
- This is not approved for use by anyone younger than 18 years old.
- Keep this at room temperature away from heat and moisture.