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What condition does Linaclotide treat?

Linaclotide is a guanylate cyclase-C agonist and a 14-amino acid peptide used for the treatment of:

  • Irritable bowel syndrome constipation
  • Chronic idiopathic constipation

These conditions are certain types of bowel problems. These have symptoms of difficult and incomplete bowel movements. These also have the symptom of abdominal pain. Linaclotide improves stool texture and reduces some symptoms such as:

  • Abdominal discomfort
  • Bloating
  • Feelings of incomplete bowel movements

This medication increases fluid in your intestines and helps speed up the movement of food through the gut. Linaclotide is supplied as a capsule that is approved by the Food and Drug Administration (FDA). This is available for oral use.

How does Linaclotide work?

Linaclotide works locally in the intestine. It is to increase bowel movements and lessen the pain. The effect of this drug is due to an increase in the production of a chemical called cyclic guanosine monophosphate. That it increases fluid secretion into the intestine and lessens the sensitivity of pain-sensing nerves.

What is the recommended dosage for Linaclotide?

This is to be taken by mouth usually once a day. You may take it at least 30 minutes before your first meal of the day. Swallow the medicine as a whole with a full glass of water. Do not break or chew the capsule.

The dosage is based on your medical condition and response to it. For the best benefit from this, take it regularly. Remember to take each dose at the same time every day. Do not take more or less than the prescription of your doctor. You must take this medication exactly as it is given.

What are the side effects of Linaclotide?

Common side effects:

  • Gas
  • Bloating
  • Heartburn
  • Vomiting
  • Headache
  • Abdominal or stomach pain
  • Diarrhea
  • Cold symptoms such as stuffy nose, sneezing, or sinus pain

What are the precautions in taking Linaclotide?

  • Before using this drug, tell your doctor if you have any allergies. Inform also your doctor if you are taking herbal products or vitamins.
  • You should not share this with others even they have the same symptoms as yours.
  • This may not be recommended for breastfeeding women or pregnant women.
  • If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your dosing schedule.
  • Linaclotide should not be given to a child younger than 6 years old. Linaclotide might cause fatal dehydration or severe diarrhea in a child. Do not give this drug to any child or teenager without the guidance of a doctor.
  • Tell your doctor if you have a blockage in your intestines or stomach. Your doctor will probably tell you not to take this medicine.
  • Linaclotide is not approved for use by anyone younger than 18 years old.
  • Stop taking this medication if you experience any side effects such as stomach pain, nausea, vomiting, blood in your stool, or diarrhea.
  • Seek medical attention right away if you notice symptoms of unexplained weight loss or severe abdominal pain.