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Lesinurad is a prescription medication used to lower uric acid. The effect of this medication is to help prevent gout flares or attacks. Increased uric acid levels can cause gout attacks. Lesinurad is a URAT1 inhibitor that also helps the kidneys get rid of uric acid. This is a prescription approved by the Food and Drug Administration (FDA).

A gout is a form of inflammatory arthritis that develops in some people who have high levels of uric acid in the blood. The acid can form needle-like crystals in a joint and cause severe episodes of pain, redness, swelling, and tenderness.

How does Lesinurad work?

Lesinurad inhibits xanthine oxidase. It is the enzyme that converts hypoxanthine to xanthine to uric acid. The inhibition of this enzyme is responsible for the effects of this medication. This drug increases the utilization of hypoxanthine and xanthine for nucleotide and nucleic acid synthesis. It is by a process that involves the enzyme hypoxanthine-guanine phosphoribosyltransferase.

This progression results in an increased nucleotide concentration that causes feedback inhibition of de novo purine synthesis. The result is decreased urine and serum uric acid concentrations, which decreases the incidence of gout symptoms.

How is Lesinurad taken?

The recommended dosage is based on your medical condition and response. You must take this prescription exactly as it is given. Do not take more or less than recommended.

This is to be taken by mouth with a full glass of water. This is usually taken once a day in the morning. Each dose is taken with food or as directed by your doctor. Drink plenty of fluids while taking this drug. Remember to take it at the same time every day. Do not take more than the recommended dosage. Follow carefully the full prescription given by your doctor for the best results.

What are the side effects of Lesinurad?

  • Headache
  • Skin rash
  • Chest pain or discomfort
  • Confusion
  • Double vision
  • Nausea
  • Sweating
  • Vomiting
  • Sweating
  • Slow speech
  • Pain or discomfort in the neck, arms, jaw, and back

What are the precautions in taking Lesinurad?

  • Do not stop taking this medication without consulting your doctor.
  • This drug may make you drowsy or dizzy. Do not drive or use any machinery that needs your alertness until you know how this drug affects you.
  • Tell your doctor if you are allergic to this drug or if you have any allergies. Call for emergency medical help if you have signs of an allergic reaction including trouble breathing, hives, or swelling of the throat and face.
  • While taking this medicine, limit alcoholic beverages. It might increase some risk of side effects.
  • This should not be used during pregnancy. If you are breastfeeding women, consult your doctor first.
  • Let your doctor know if you ever had a stroke, liver disease, or high blood pressure. Also, if you have any medications, vitamins, herbal products, or food supplements let your doctor know.
  • Call your doctor right away if you get pregnant while taking Lesinurad.
  • Keep this prescription and your other medicines in a safe place, far from heat and moisture.