Lenvatinib

September 28, 2021

Medicine

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What condition does Lenvatinib treat?

Lenvatinib is used to treat certain kinds of cancer such as:

• A type of cancer that is progressing and can no longer be treated with radioactive iodine called Differentiated thyroid cancer (DTC)
• A type of liver cancer called hepatocellular carcinoma (HCC)
• A type of kidney cancer called advanced renal cell carcinoma (RCC)

This medication may be used alone or with other medications to treat a certain condition.

Lenvatinib is known as a tyrosine kinase inhibitor. These blocks the action of an abnormal protein that signals cancer cells to grow and develop. This is a prescription approved by the Food and Drug Administration (FDA). Lenvatinib comes as a capsule for oral use.

How does Lenvatinib work?

Lenvatinib targets and binds to the tyrosine kinase receptors. They inhibit vascular epidermal growth factor receptors and vascular endothelial growth factors. This medication also prevents other kinase receptors that have been implicated in tumor growth, pathogenic angiogenesis, and cancer progression. In addition to their normal cellular functions, it includes platelet-derived growth, fibroblast growth factor receptors, and KIT and RET on the surface of the cell. By binding to these receptors, Lenvatinib blocks important pathways that promote cell division.

What is the recommended dosage for Lenvatinib?

The recommended dosage is based on your medical condition and response. You must follow the directions that are given by your doctor. Do not take more or less than the prescription.

Lenvatinib is to be taken by mouth. Swallow the capsule as a whole with a full glass of water. Usually, this medicine is taken once a day. You may take each dose with or without a meal. To help you remember, take it at the same time every day.

Your doctor may reduce your dose or tell you to stop taking the medication for a time or permanently if you experience serious side effects. Make sure to discuss with your doctor how you are feeling during your treatment. The length of your treatment depends on the side effects you will experience and how well you respond to the medication. Continue to take this medicine even if you feel well. Do not stop taking it without talking to your doctor.

What are the side effects of Lenvatinib?

• Diarrhea
• Muscle or joint pain
• Nausea
• Weight loss
• Vomiting
• Headache
• Decreased appetite
• Abdominal pain
• Mouth pain
• Constipation
• Cough
• Swelling of the feet or hands
• Dry mouth
• Changes in the sense of taste
• Dizziness
• Rash
• Hair loss
• Lack of energy or weakness
• Insomnia

What are the precautions in taking Lenvatinib?

• Before taking this medicine, tell your doctor if you have a medical history, current medication, or allergies.
• Do not use this to treat another condition without the permission of your doctor.
• For those women who are pregnant or may become pregnant, you should not handle this medication or breathe the dust from the capsule.
• This is not recommended for use in breastfeeding women.
• You should know that your blood pressure may increase during your treatment with this medicine. Your doctor will perhaps monitor your blood pressure throughout your treatment.