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Where is Ivosidenib used?

Ivosidenib is a medicine used in people with acute myeloid leukemia (AML). This is also used to treat AML that has not improved or has come back after prior treatment. This medication is used only in patients who have an isocitrate dehydrogenase-1 (IDH1) mutation in their AML. This is an FDA-approved prescription for oral use.  

How does Ivosidenib work?

Ivosidenib is a type of targeted therapy called an isocitrate dehydrogenase-1 (IDH1) inhibitor. This works by directing and hindering IDH 1 enzyme. In several cancers, this receptor is intense that causes cells to develop and split too fast. By preventing these, Ivosidenib can slow or stop the growth of the tumor. Your doctor will test your tumor for this abnormality, which needs to be present to receive the medication.

How is Ivosidenib taken?

  • This medicine may be taken with or without food. Take it as a whole with a glass of water. Do not break or chew it. 
  • Do not take each dose with a high-fat meal.
  • Avoid eating grapefruit and drinking grapefruit juice.
  • Take the medicine at the same time every day.
  • Take this prescription as prescribed.
  • Do not change or stop taking unless told to do so by your health care provider.
  • If you missed a dosage, it is important to call your doctor for instructions. Do not take an extra dose of this medicine the following day to make up for the missed one. 
  • Do not take another dose if you vomit after taking a dose. Wait until the next scheduled dose.
  • Take this medication until the full prescription is finished. Do not suddenly stop taking this without the approval of your doctor.
  • Take this drug regularly for the best benefit.

What are the possible side effects of Ivosidenib?

  • Fever
  • Cough
  • Vomiting
  • Loss of appetite
  • Constipation
  • Headache 
  • Nausea
  • Diarrhea
  • Fatigue 

What are the precautions in taking Ivosidenib?

  • Before starting this treatment, make sure you inform your doctor about any other medications you are taking. Do not take aspirin or products having aspirin unless your doctor exactly recommended this.
  • Certain medicines can increase the amount of Ivosidenib in your body. Discuss to your pharmacist or physician before starting a new medication.
  • This drug may change the effectiveness of hormonal birth control. Use backup methods while having treatment with this medicine.
  • Do not receive any kind of vaccination/immunization without the approval of your doctor while taking this medicine.
  • Tell your health care professional if you are pregnant or may be pregnant before starting this treatment. 
  • Do not breastfeed while taking this medication for at least 1 month after the last dose.
  • To lessen nausea, take anti-nausea medicines as prescribed by your doctor and eat small, frequent meals.
  • You may experience dizziness or drowsiness. Avoid driving or engaging in tasks that need alertness until your response to the drug is identified.
  • If you experience side effects, make sure to discuss them with your doctor. They can prescribe medicines and recommend some other suggestions that are effective in managing such problems.