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Indomethacin

Formula Drugs

Where it is used and how does it work?

Indomethacin is used in adults to relieve pain and inflammation in a wide range of conditions including:

  • Osteoarthritis 

This is the most common form of arthritis which affects millions of people. It happens when the defensive cartilage that cushions the ends of your bones wears down over time. Although this condition can damage any joint, it most commonly affects joints in your knees, hands, hips, and spine. The symptoms of this condition can usually be managed, though the damage to joints can’t be reversed. Keeping a good weight, staying active, and some treatments might slow the progression of the disease. It may as well help improve pain and joint function. Osteoarthritis symptoms frequently progress slowly and get worse over time. 

  • Rheumatoid arthritis 

This is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage a wide variety of body systems (eyes, skin, lungs, heart, or blood vessels). An autoimmune disorder, rheumatoid arthritis happens when your immune system mistakenly attacks your own body’s tissues. Not like the tear-and-wear impairment of osteoarthritis, rheumatoid arthritis affects the lining of your joints that causes painful swelling. It can eventually result in bone erosion and joint deformity.

  • Acute gout

This condition is characterized by sudden and severe attacks of pain, swelling, and tenderness in the joints. An attack of gout can happen suddenly. It may be waking you up in the middle of the night with the sensation that your big toe is on fire. The affected joint is swollen and hot. It is so tender as well that even the weight of the sheet on it may seem intolerable. Gout symptoms may come and go. But, there are ways to manage symptoms and prevent flares.

  • Dysmenorrhea

Are cramping pains on the lower abdomen. Many women experience menstrual cramps just before and during their menstrual periods. For some women, the discomfort is merely annoying. For others, menstrual cramps can be severe enough to interfere with everyday activities for a few days every month.

The Food and Drug Administration (FDA) has already approved this prescription. This drug is known as a nonsteroidal anti-inflammatory drug (NSAID). This blocks your body’s production of certain natural substances that cause inflammation. The effect of Indomethacin helps to decrease swelling and pain. 

Indomethacin blocks the action of a substance in the body called cyclo-oxygenase (COX). COX is involved in the production of various chemicals in the body. Some of which are known as prostaglandins. These are produced by the body in response to injury and certain diseases and conditions. It causes inflammation, pain, and swelling. Indomethacin blocks the creation of these prostaglandins and as a result, this is effective at decreasing pain and inflammation. 

Indomethacin provides prolonged pain relief so this is to be taken exactly as directed by your doctor. The capsules must be swallowed whole to avoid damaging the modified-release action.

How to take the medication?

This is to be taken by mouth usually 2 to 3 times a day or as directed by your doctor. Swallow the capsule as a whole with a full glass of water. Do not break, chew, or crush it. Do not lie down for at least 10 minutes after taking this drug. If stomach upset happen, take it with food, antacid, or milk. The dosage is based on your medical condition and response to the treatment. To lessen the risk of stomach bleeding and other side effects, take this at the lowest effective dose for the shortest possible time. Do not increase your dose or use this drug more often or for longer than the prescription. Remember to take this prescription in the same way and at the same time each day. 

Before you notice the full benefits, it may take up to 4 weeks when this drug is taken regularly in certain conditions. If you are taking this drug on an as-needed basis, remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well. Let your doctor know if your condition does not improve. If you missed a dose, call your doctor for instructions. Do not twice the dosage to make up for the missed dose. 

Common and Serious Side Effects

  • Fainting
  • Hot flashes 
  • Loss of appetite
  • Sweating
  • Drowsiness
  • Rash
  • Light-headedness 
  • Diarrhea
  • Itching
  • Bleeding
  • Indigestion
  • Constipation
  • Vomiting
  • Dizziness
  • Headache
  • Swelling or edema
  • Nausea

Call for medical help if you experience signs of an allergic reaction including:

  • Hives 
  • Difficulty or trouble breathing 
  • Swelling in your lips, throat, face, or mouth 

Things to Remember

  • Indomethacin may cause dizziness that may affect your capacity to operate machinery or drive safely. Do not operate machinery or drive until you know how this medicine affects you and you are sure it won’t affect your performance.
  • The lowest effective dose of this medicine will be given by your doctor. It may be for the shortest possible time needed to relieve your symptoms. This is to minimize the chances of any side effects. It is important not to exceed the prescribed dose.
  • Certain medicines should not be used during breastfeeding or pregnancy. However, other medicines may be safely used in breastfeeding or pregnancy providing the benefits to the mother outweighs the risks to the unborn baby. Inform your doctor if you are planning a pregnancy or pregnant, before using any medication. 
  • Let your doctor if you ever had an allergic reaction to this drug. Tell as well if you have any allergies. This medication may contain an ingredient that causes an allergic reaction. 
  • Use this with caution in people with a history of disorders that affects the stomach, who have inflammatory bowel disease, decreased kidney or liver function, heart failure, or high blood pressure. 
  • For people with a history of stroke, heart disease, poor blood circulation in the arteries of the legs, high cholesterol levels, diabetes, or smoker, this prescription should as well be sued carefully. 
  • Indomethacin is not recommended for use in children, people with nasal polyps, active peptic ulcers, severe kidney or liver failure, severe heart failure, or in people who are allergic to aspirin.