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Ibritumomab Tiuxetan

Ibritumomab Tiuxetan

Where is Ibritumomab Tiuxetan used?

Ibritumomab Tiuxetan is a monoclonal antibody that is used for the treatment of non-Hodgkin’s lymphoma. This drug is linked with a radioactive substance Yttrium-90 which is a manmade antibody that has a radioactive isotope attached to deliver radiation therapy to the lymphoma cells. The Food and Drug Administration has approved this prescription for medical use.

How does Ibritumomab Tiuxetan work?

A monoclonal antibody is a relatively new type of targeted cancer therapy. The antibody is an integral part of the immune system. Usually, the body makes antibodies in response to an antigen that has entered the body. This type of therapy is usually given only for cancer in which antigens have been identified already.

Ibritumomab Tiuxetan works by targeting the CD20 antigen on malignant and normal B-cells. On the other hand, it is more than a monoclonal antibody alone. The experts have shown, Yttrium-90 is linked to the antibody. Once the antibody is attached to the CD20 antigens, radiation is delivered straight to the targeted cells. It kills the targeted cells and cancer cells. This allows healthy B-cells to regenerate after treatment.

How is Ibritumomab Tiuxetan used?

  • Ibritumomab Tiuxetan is given through intravenous infusion. It is given only as part of a protocol in combination with certain medications.
  • The infusion with this drug is started at a slow rate and increased if no allergic reaction or infusion-related occurs.
  • Usually, the infusion time is about 4 to 6 hours. A radiolabeled tracer is injected for 10 minutes within 4 hours after the infusion.
  • After infusion, body scans are done 2 to 24 hours, 48 to 72 hours, and 96 to 120 hours later to monitor the distribution of the medicine through the body.
  • The amount of this medication that you will receive is based on your weight, height, overall health, and the type of cancer being treated. Your doctor will determine your dosage and schedule.

What are the possible side effects of Ibritumomab Tiuxetan?

Infusion-related side effects:

Low red blood cell count:

  • Feeling tired or weak
  • Difficulty breathing
  • Shortness of breath
  • Chest pain

Low platelet count:

  • Excess bleeding or bruising including blood in your urine, nose bleeds, or bleeding gums.

It is important to let your doctor know right away if you experience any of these side effects.

What are the precautions in taking Ibritumomab Tiuxetan?

  • Make sure to inform your doctor about any medications you are taking. Do not take aspirin or any products that have aspirin unless it is permitted by your doctor.
  • Do not receive vaccination or immunization without the consent of your doctor while you are having treatment with this drug.
  • Let your doctor know if you may be pregnant or pregnant before starting this treatment. Pregnant women must be guided of the possible risk to the fetus.
  • Do not breastfeed while having this treatment.
  • You may be at risk of infection. Avoid people who are not feeling well and avoid crowds. Report fever or any other signs of infection right away to your doctor.