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What condition does Estropipate treat?

Estropipate is used by women to help reduce symptoms of menopause like vaginal dryness and hot flashes. Menopause is a normal part of aging that frequently happens between 45-55 years of age, as a woman’s estrogen levels decline. These symptoms are caused by the body making less estrogen. Certain estrogen products may also be used by women after menopause. It will help prevent bone loss or osteoporosis.

Estropipate belongs to the group of medications known as estrogen replacement therapy. It is a hormone that is produced by the ovaries. This is available as tablets for oral use. The Food and Drug Administration (FDA) approved this medication.

How does Estropipate work?

Estropipate acts by regulating the transcription of a limited number of genes. Estrogens diffuse through cell membranes and distribute themselves throughout the cell. It also binds to and activates the nuclear estrogen receptor. It is a DNA-binding protein that is found in estrogen-responsive tissues. The activated estrogen receptor binds to specific hormone-response elements or DNA sequences. It enhances the transcription of adjacent genes and in turn, leads to the observed effects. Estrogen receptors have been identified in tissues of the reproductive tract, pituitary, breast, liver, hypothalamus, and bone of women.

What is the recommended dosage for Estropipate?

The recommended dosage for this drug is based on medical condition and response.

This drug is to be taken by mouth with a full glass of water. You may take it with or without food. You may also take it right after a meal to avoid stomach upset. Take it at the same time each day. Do not take it more than the prescription of your doctor.

What are the side effects of Estropipate?

  • Nausea
  • Stomach upset
  • Loss of appetite
  • Vomiting
  • Breast tenderness or swelling
  • Bloating
  • Weight changes
  • Migraine or headache
  • Decreased sex drive
  • Acne or skin color changes
  • Dizziness
  • Changes in your menstrual periods
  • Swelling of your ankles or feet

What are the precautions in taking Estropipate?

  • This is not recommended to use in pregnant women. If you are breastfeeding, talk to your doctor first.
  • Tell your doctor if you are allergic to this drug or if you have any allergies. This may contain an inactive ingredient that may cause an allergic reaction.
  • Inform your doctor about the medical history you have had as well as your current medications.
  • This medicine may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe progestin to help lower this risk. 
  • While having this treatment, avoid smoking. It can greatly increase your risk of stroke, blood clots, or heart attack while using this drug.
  • Grapefruit may interact with this medicine and lead to unwanted side effects. Avoid the use of grapefruit products.
  • This medicine may cause dark areas on your face and skin. Limit your time in the sun. Avoid sunlamps and tanning booths. Wear protective clothing and use sunscreen when outdoors.
  • If you wear contact lenses or are near-sighted, you may develop trouble wearing your contact lenses or vision problems. Contact your eye doctor if these problems occur.