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Atovaquone-Proguanil Hydrochloride

Formula Drugs

What condition does Atovaquone-Proguanil Hydrochloride treat?

Atovaquone-Proguanil Hydrochloride is recommended for use to treat and prevent malaria. Malaria occurs because of mosquito bites in places where malaria is common. Malaria parasites could go into the body over these mosquito bites. They may also live in body tissues, including red blood cells and other tissues. For some, you may need to take another medication to complete your treatment. Both medicines require a complete cure. It will also prevent the return of the infection.

Atovaquone-Proguanil Hydrochloride belongs to the class of medications called antimalarials. The medicine is a fixed-dose combination of antimalarial agents. Atovaquone-Proguanil Hydrochloride is an FDA-approved prescription for oral use.

How does Atovaquone-Proguanil Hydrochloride work?

Atovaquone blocks mitochondrial electron transfer. Therefore, the productions of energy for use by the parasites stop.

Proguanil Hydrochloride metabolizes into its active metabolite called cycloguanil. It blocks dihydrofolate reductase and enzymes needed for making pyrimidine.  Pyrimidine is a chemical required for the production of DNA.

What is the recommended dosage for Atovaquone-Proguanil Hydrochloride?

The recommended dosage will depend on your medical condition, age, and response. Take it precisely as advised by your doctor. Please do not take more often or more than your doctor gives it. The medicine is to take as a whole with a full glass of water.

To prevent illness, take this medicine, usually once daily at the same time each day. Start this medication 1-2 days before you enter the malarious area. Continue to take the drug while in the area and for seven days after leaving. This medication is to be taken by mouth. You may take each dose with food or a milky drink that contains fat. Repeat the amount if you vomit an hour after taking this drug. Call your doctor right away if you have continuous vomiting after taking Atovaquone-Proguanil Hydrochloride. You may need another medicine to prevent vomiting or different malaria medication.

If needed, Primaquine can be taken for 14 days starting during the last week of treatment with Atovaquone-Proguanil Hydrochloride or starting right away after you have finished treatment. When using this drug for treatment, tell your doctor if your condition persists or worsens.

What are the side effects of Atovaquone-Proguanil Hydrochloride?

  • Vomiting
  • Nausea
  • Upset stomach
  • Abdominal pain
  • Diarrhea
  • Headache
  • Loss of appetite
  • Weakness
  • Dizziness
  • Itching

What are the precautions in taking Atovaquone-Proguanil Hydrochloride?

  • Do not use this medication for the treatment of other conditions without the prescription of a doctor.
  • If you have any medical history, especially kidney problems, current vomiting, or seizures, it is vital to inform your doctor.
  • Before having surgery, tell your doctor or dentist about all the products you use, including non-prescription drugs, prescription drugs, and herbal products.
  •  Let your doctor if you have any allergies. Call for medical help right away if there are any signs of an allergic reaction occur.
  • This drug may make you dizzy. Do not drive, use machinery, or do anything that needs alertness until you safely do it.
  • Keep this at room temperature, away from heat or moisture.