Latest Post

Formula Drugs

Favipiravir

Favipiravir is an influenza drug which was approvedfor cli...

Trospium Chloride

Trospium Chloride

TrospiumChloride is in the class of medication called antispasmodics. This is used forthe treatment of overactive bladder. This develops your capability to regulateyour urination by calming the muscles in the bladder. It helps to decreasefeelings of needing to urinate right away, leaking of urine and frequent tripsto the bathroom. Trospium Chloride comes as a tablet for oral use. Each tabletis available in the dosage strength of 20 mg. The Food and Drug Administration(FDA) has already approved this product. 

Overactivebladder is a disorder in which the bladder squeezes urineout at the wrong time. You can have this condition if you have two or more ofthe following symptoms:

  • You have the sudden or strong need to urinate rightaway
  • You urinate eight or more times a day and two ormore times at night 
  • You leak urine after a sudden or strong urge tourinate

Even ifit’s not rare among older adults, overactive bladder is considered as not ausual part of aging. Talk to your doctor if your symptoms disrupt your life ordistress you. You may as well have incontinence which is a loss of bladder control.If you have an overactive bladder, you may isolate yourself, feel embarrassed,or limit your work and social life. The good news is that a brief assessmentcan define whether there’s an exact cause for your overactive bladdersymptoms. 

Controllingoveractive bladder frequently begins with behavioral strategies such as timedvoiding, adder-holding techniques, and fluid schedules by your pelvic floor. Ifthese strategies don’t support sufficient with your overactive bladdersymptoms, prescriptions are accessible. 

How doesTrospium Chloride work?

TrospiumChloride is a type of drug called an antimuscarinic muscle relaxant. It relaxesthe involuntary muscle that is found in the wall of the bladder. 

Themuscle in the wall of the bladder is called the detrusor muscle. At times itmight contract in strong spasms. This is frequently stated as having anoveractive bladder. The overactive detrusor muscle can increase in the numberof times you need to pass urine or cause uncontrollable urges to pass urine. Itmay as well be an involuntary leakage of urine. 

TrospiumChloride relaxes the detrusor muscle in the wall of the bladder. It does thisby blocking receptors called muscarinic receptors that are found on the surfaceof the muscle cells. This inhibits acetylcholine which is an ordinary bodychemical from acting on these receptors.

Usually,when acetylcholine acts on these receptors, it causes the detrusor muscle tocontract and the bladder to empty. By blocking acetylcholine, this drug helpsthe muscle in the bladder wall to relax. This decreases unbalanced andinvoluntary contractions of the bladder. Thereby, it increases the capacity ofthe bladder to hold urine. In turn, this lessens the need to pass urine.

How touse Trospium Chloride?

This isto be taken usually twice a day by mouth. Each dose is taken on an emptystomach or 1 hour before meals. It is sometimes taken once a day at bedtime.The dosage will depend on your medical condition and response to the treatment.Swallow the tablet as a whole. Do not break or crush the tablet. Avoid drinkingalcohol or taking any product that contains alcohol for 2 hours before andafter taking this drug. Alcohol can destroy the long action of the drug and mayincrease side effects.

To helpyou remember, take it at the same time each day. Use this medication regularlyto get the most benefit from it. You should not take more or less or take itmore often than it is given by your doctor. Let your doctor know if yourcondition does not improve or if it worsens.  

What arethe side effects of Trospium Chloride?

Commonside effects:

  • Constipation
  • Dry mouth or throat
  • Gas
  • Stomach upset
  • Dry eyes
  • Headache
  • Blurred vision
  • Dizziness
  • Drowsiness

Thefollowing symptoms are uncommon but if you experience any of them, call yourdoctor right away:

  • Rash, itching or hives 
  • Difficulty urinating
  • Swelling of the lips, face, tongue, throat, eyes,hands, ankles, feet, or lower legs
  • Difficulty swallowing or breathing
  • Hallucinations – seeing things or hearing voicesthat do not exist
  • Confusion or mental/mood changes 

Warningsand Precautions

  • Trospium Chloride may contain an inactiveingredient that causes an allergic reaction. Let your doctor know if you haveany allergies. If there are any signs and symptoms of allergies, call yourdoctor right away. 
  • Before using this drug, tell your doctor if youhave any medical history especially of liver or kidney disease, glaucoma,inability to urinate, or intestinal/stomach problems. 
  • This medication may make you dizzy or drowsy. Donot use any machinery or perform any activity that needs your alertness. 
  • Avoid drinking alcohol while having TrospiumChloride. 
  • Trospium Chloride may make you sweat fewer. That itmakes you more likely to get heatstroke. You must avoid performing things thatcan cause you to overheat. It may be hard work or exercise in hot weather. Ifit is hot weather, drink a lot of water or fluids and dress lightly. Quicklylook for a place to cool down and rest if you overheat. 
  • Your doctor should reassess whether you still needtreatment with this drug every 3-6 months. 
  • Trospium Chloride is not recommended for use inchildren under 12 years old. 
  • In case there are any signs of an overdose, callfor medical help right away or call also your doctor. 
  • It is important to keep all medication out of sightand reach of children or from your pets. 
  • Keep this medication in the container it came inand tightly closed.

This drugshould be used with caution in people with:

  • Obstruction of the outflow of urine from thebladder.
  • Obstruction or decreased motility of the stomach orintestines, such as pyloric stenosis.
  • Disorder of the involuntary nerves that control theinternal organs
  • Heart disease
  • Hiatus hernia 
  • Overactive thyroid gland

This drugshould not be used in people with:

  • Abnormal muscle weakness
  • Closed-angle glaucoma
  • Severe inflammation of the bowel and back passage
  • Fast or abnormal heart rhythms
  • Rare hereditary problems of galactoseintolerance