Latest Post

Formula Drugs

Niraparib Capsule

Niraparibis indicated as a maintenance treatment for the r...

Tetrabenazine

Tetrabenazine

Where it is used and how it works?

Tetrabenazineis used to help control Huntington’s disease, senile chorea, and hemiballismus.This also helps to control a movement disorder called tardive dyskinesia. 

Thismedicine works by reducing the rations of definite neurotransmitters within thenerve cells in the brain. These neurotransmitters include dopamine,noradrenaline, and serotonin. They are involved in passing messages betweennerve cells in the brain and the normal functioning of the brain and nervoussystem. Reducing the brain cells of these neurotransmitters helps to stop thenerve cells from sending unsuitable messages to the muscles. It can helpcontrol jerky, irregular and uncontrollable movements that are the result of certaindiseases of the brain and nervous system. 

Huntington’sdisease 

This is arare inherited condition that causes the advanced breakdown of nerve cells inthe brain. Huntington’s disease has a broad impact on a person’s functionalabilities and usually results in movement, thinking, and psychiatric disorders.This disease’s symptoms can develop at any time, but they frequently firstappear when people are in their 30s or 40s. If the condition develops beforeage 20, it’s called juvenile Huntington’s disease. When Huntington developsearly, symptoms are somewhat different and the disease may progress faster.Huntington’s disease usually causes movement, cognitive, and psychiatricdisorders with a wide spectrum of signs and symptoms. Some symptoms appear moredominant or have a greater effect on functional ability, but that can changethroughout the disease. This condition is caused by an inherited defect in asingle gene. Huntington’s disease is an autosomal dominant disorder, whichmeans that a person needs only one copy of the defective gene to develop thedisorder. Except for genes on the sex chromosomes, a person inherits two copiesof every gene. A parent with a defective gene could pass along the defectivecopy of the gene or the healthy copy. Each child in the family, therefore, hasa 50% chance of inheriting the gene that causes the genetic disorder.

Senilechorea

This is arelatively mild and uncommon disorder that occurs in elderly adults and ischaracterized by choreic movements. Chorea refers to rapid complex bodymovements that look well-coordinated and purposeful but are, in fact,involuntary. 

Hemiballismus

This isthe most common degenerative disorder causing chorea. In Huntington disease,drugs that suppress dopaminergic activity and dopamine-depleting drugs can beused to treat chorea. Antipsychotics may also help by lessening theneuropsychiatric symptoms commonly associated with Huntington disease. However,improvement may be limited and transient. All of these drugs may be judiciouslyused to treat choreas without a definable cause.

Tardivedyskinesia

This is aside effect caused by neuroleptic drugs. This condition causes uncontrolled orinvoluntary movements. They are often prescribed for psychiatric disorders andneurological disorders. Sometimes neuroleptic drugs are prescribed forgastrointestinal disorders. These drugs block dopamine receptors in the brain.Dopamine is a chemical that helps control emotions and the pleasure center ofyour brain. It also plays a role in your motor functions. Too little dopaminemay interfere with your muscles and cause the signs and symptoms of Tardivedyskinesia. Mild to moderate cases of Tardive dyskinesia cause stiff, jerkingmovements of the:

  • Jaw
  • Face
  • Lips
  • Tongue

Thesemovements may include blinking frequently and sticking the tongue out. Peoplewith moderate cases of this condition often experience additional uncontrolledmovement in the:

  • Arms
  • Toes
  • Fingers
  • Legs

TheRecommended Dosage

Thestarting dose should be 12.5 mg per day given once in the morning. After oneweek, the dose should be increased to 25 mg per day given as 12.5 mg twice aday. This drug should be titrated up slowly at weekly intervals by 12.5 mgdaily, to allow the identification of a tolerated dose that reduces chorea. Ifa dose of 37.5 to 50 mg per day is needed, it should be given in a three timesa day regimen. The maximum recommended single dose is 25 mg. 

Tetrabenazineshould be swallowed with a full glass of water. They can be taken either withor without a meal. The dose of this medicine that is prescribed and how oftenit needs to be taken depends on the condition being treated. It is important tofollow the instructions given by your doctor. If you forget to take a dose takeit as soon as you remember unless it is nearly time for your next dose. In thiscase, just leave out the forgotten dose and take your next dose as usual. Don’ttake a double dose to make up for a missed dose. You should not suddenly stoptaking this medicine unless your doctor tells you to. If treatment with thismedicine is stopped, this should usually be done gradually.

Its SideEffects

  • Insomnia
  • Drowsiness
  • Tired feeling
  • Nausea
  • Breast swelling or discharge
  • Sleep problems or insomnia
  • Feeling anxious or irritable
  • Cold symptoms

Tell yourdoctor if you have serious side effects of Xenazine including:

  • Extreme drowsiness
  • Mood or behavior changes
  • Restlessness
  • Agitation 
  • Trouble swallowing
  • Problems with balance
  • Dizziness
  • Fast or pounding heartbeat
  • Fainting 
  • Very stiff muscles, high fever, sweating, 
  • Muscle pain or tenderness with fever or flu symptoms 
  • Urinating less than usual or not at all, weight gain, swelling, or shortness of breath.

Warningsand Precautions

  • Do not drink alcohol while you are taking this medicine. This is likely to make you feel drowsy or dizzy that you may experience worse.
  • Certain medicines should not be used during breastfeeding or pregnancy. However, other medicines may be safely used in breastfeeding or pregnancy providing the benefits to the mother outweighs the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. 
  • Tetrabenazine should be given carefully in people with a history of depression, decreased liver or kidney function, and a history of abnormal heart rhythms. 
  • This drug is not recommended for use in people with depression, Parkinson’s disease, or people taking a MOAI antidepressant in the last two weeks. 
  • Never share this or any of your medicines with others even if they have the same symptoms as yours.