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Bicalutamide (Casodex) for Oral Use
Bicalutamide (Casodex) is indicated for the treatment of prostate cancer. This medication is used with another drug, LHRH-type like goserelin and leuprolide. Prostate cancer happens in the prostate. It is a slight walnut-shaped gland in men that makes the seminal fluid nourishes and transports sperm. It usually grows slowly.
How does Bicalutamide (Casodex) work?
Bicalutamide (Casodex) competitively prevents the act of androgens. It is by binding to cytosol androgen receptors in the target tissue. Prostatic carcinoma is known to be androgen sensitive. It also responds to the effect of androgen and eliminates the source of androgen.
When this medication is united with LHRH analog therapy, the suppression of serum testosterone made by the LHRH analog is not affected. Still, in clinical trials with Bicalutamide (Casodex) as a single agent for prostate cancer, it rises in serum testosterone and estradiol has been noted.
Why use Bicalutamide (Casodex)?
Bicalutamide (Casodex) is a non-steroidal androgen receptor inhibitor. Androgens are hormones that the adrenal gland is making and releasing. This medication blocks the action of male hormones in the prostate. This also slows the growth of cancer cells. Bicalutamide (Casodex) was approved by the Food and Drug Administration (FDA) in 1995.
How to use Bicalutamide (Casodex)?
The prescribed dosage will depend on your condition and response to the treatment.
This medication should be taken as one 50mg in the morning or evening. Take this at the same time each day. You may take this with or without food. Once the treatment has started, it should not be interrupted or stopped without consulting your doctor.
What are the side-effects of Bicalutamide (Casodex)?
- Stomach upset
- Loss of appetite
- Sore throat
- Loss of interest in sex
- Runny nose
- Trouble having an orgasm
- Weight changes
- Hair loss
- Increased night-time urination
- Trouble sleeping
- Back, joint/muscle pain
- Flushing and sweating (hot flashes)
- Breast swelling/tenderness/pain
Let your doctor know if you have serious side effects like:
- Numbness or tingling of the hands or feet
- Vision changes
- Swelling of the arms or legs
- Unusual or easy bleeding or bruising
- Painful urination
- Trouble breathing
- Mood/mental changes
Warnings and Precautions
- This is not prescribed in pregnant or breastfeeding women.
- Tell your doctor if you have had a medical history especially of diabetes, liver or heart disease.
- If there is an allergic reaction, call for medical help right away.