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Adcetris (Brentuximab Vedotin) for Injection

Formula Drugs

General Information

Adcetris (Brentuximab Vedotin) is used to treat classical Hodgkin’s lymphoma that could relapse or has already relapsed after a stem cell transplant. This can also be used in combination with other cancer medications. Adcetris is also used to treat anaplastic large cell lymphoma that affects organs throughout the body (systemic). This is usually given for these conditions after other treatments have failed.

 

How does Adcetris (Brentuximab Vedotin) work?

Brentuximab Vedotin has the part of an antibody type of targeted therapy. Antibodies are an integral part of the body’s immune system. It is usually the body makes antibodies in reaction to an antigen that has entered the body. The antibodies attach to the antigen in order to mark it for destruction by the immune system. This medication is a CD30-directed Antibody Drug Conjugate (ADC). It consists of an antineoplastic (chemotherapy) agent and a targeted therapy monoclonal antibody. This works together to destroy cancer cells.

The Brentuximab portion of the drug is a monoclonal antibody which targets the CD30 antigen on the surface of the cancer cells. When it attaches itself, it allows the ADC to enter the cell. It will also disrupt the microtubule network which is part of the structural network of the cell. This disruption stops the cell from dividing and copying itself. This disruption eventually leads to cell death.

 

Why use Adcetris (Brentuximab Vedotin)?

Adcetris (Brentuximab Vedotin) is a cancer medication that interferes with the spread and development of cancer cells in the body. This is in a class of medications known as antibody-drug conjugates. This treatment was approved for anaplastic large cell lymphoma by the US Food and Drug Administration (FDA).

 

How to use Adcetris (Brentuximab Vedotin)?

Adcetris (Brentuximab Vedotin) comes as a powder to be mixed with fluid. It is injected over 30 minutes intravenously by a doctor or nurse. If this is given to treat Hodgkin’s lymphoma, it is usually injected once every 3 weeks for as long as your doctor recommends that you receive treatment. If this is used in combination with chemotherapy to treat Hodgkin lymphoma as a first treatment, it is usually injected once every 2 weeks.

 

What are the side-effects of Adcetris (Brentuximab Vedotin)?

  • Dizziness
  • Headache
  • Constipation
  • Cough
  • Itching
  • Vomiting
  • Muscle or joint pain
  • Hair loss

 

Warnings and Precautions

  • This medication may cause serious allergic reactions, which usually happens during the infusion of the medication or within 24 hours of receiving a dose. You may receive certain medications before your infusion to prevent an allergic reaction if you had a reaction with previous treatment.
  • There may be a hypersensitivity reaction that may occur up until 24 hours after infusion. Call your doctor if this happens.
  • This treatment may not be prescribed to pregnant or breastfeeding women. Consult a doctor first for your safety.